How are thyroid nodules evaluated for cancer risk and when is biopsy indicated?

How are thyroid nodules evaluated for cancer risk and when is biopsy indicated?

• A. Ultrasound features such as hypoechogenicity, irregular margins, microcalcifications, taller-than-wide shape, and increased vascularity; suspicious features or size thresholds warrant biopsy.
• B. Nodule with smooth margins always requires biopsy.
• C. All nodules should be biopsied regardless of features.
• D. Normal ultrasound negates biopsy.

Answer: (A)